Graphical Summary of Our Research Program

Our laboratory seeks to define fundamental principles of GPCR signaling by integrating structural biology, functional genomics, and computational modeling.

By linking genetic variation to signaling mechanisms, we aim to advance precision diagnosis and therapies for rare and common diseases.





Representative Publications

  1. The structure and function of the ghrelin receptor coding for drug actions.
    Shiimural Y*, Im D, Tany R, Asada H, Kise R, Kurumiya E, Wakasugi-Masuho H, Yasuda S, Matsui K, Kishikawa J, Kato T, Murata T, Kojima M, Iwata S* and Masuho I*
    Nature Structural & Molecular Biology (2025)
    *Corresponding authors

  2. Rules and mechanisms governing G protein coupling selectivity of GPCRs.
    Masuho I*, Kise R, Gainza P, Moo EV, Li X, Tany R, Wakasugi-Masuho H, Correia BE, and Martemyanov KA*.
    Cell Reports (2023)
    *Corresponding authors

  3. Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling.
    Masuho I*, Skamangas NK, Muntean BS, Martemyanov KA*.
    Cell Systems (2021)
    *Corresponding authors

  4. A global map of G protein signaling regulation by RGS proteins.
    Masuho I, Balaji S, BMuntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA.
    Cell (2020)

  5. Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling.
    Masuho I, Chavali S, Muntean BS, Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, and Babu MM, Martemyanov KA.
    Cell Reports (2018)

  6. Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
    Masuho I, Ostrovskaya O, Kramer GM, Jones CD, Xie K, Martemyanov KA.
    Science Signaling (2015)


Funding

  1. R35GM156391
    Masuho (PI)
    07/01/2025-06/30/2030
    The major goal of this project is to elucidate the mechanisms of G protein selectivity in GPCR signaling, with the ultimate aim of informing the development of more selective and effective GPCR-targeted therapies.


Not by weaving complex theories, not by building speculative philosophies, do I desire a deep understanding of simple and beautiful truths.

増保 生郎
Ikuo Masuho, PhD
E-mail: Ikuo.Masuho@SanfordHealth.org

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