Research Interests

We study molecular and cellular aspects of G protein-coupled receptor (GPCR) signaling. GPCRs are the largest class of cell-surface receptors and are activated by a diverse range of ligands, including sensory stimuli, hormones, and neurotransmitters. They play crucial roles in cellular functions such as chemotaxis and synaptic plasticity, and are involved in virtually all physiological processes. Because of their importance, it is not surprising that GPCR signaling has been implicated in a multitude of human disorders (cancer, neurological disorder, metabolic disease, viral pathogenesis, etc.) and is the target of many therapeutic agents. Thus, understanding the signaling pathways at the molecular level is among the highest public health research priorities.

Representative Publications

  1. Rules and mechanisms governing G protein coupling selectivity of GPCRs.
    Masuho I*, Kise R, Gainza P, Moo EV, Li X, Tany R, Wakasugi-Masuho H, Correia BE, and Martemyanov KA*.
    Cell Reports (2023)
    *Co-corresponding authors

  2. Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling.
    Masuho I*, Skamangas NK, Muntean BS, Martemyanov KA*.
    Cell Systems (2021)
    *Co-corresponding authors

  3. A global map of G protein signaling regulation by RGS proteins.
    Masuho I, Balaji S, BMuntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA.
    Cell (2020)

  4. Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling.
    Masuho I, Chavali S, Muntean BS, Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, and Babu MM, Martemyanov KA.
    Cell Reports (2018)

  5. Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
    Masuho I, Ostrovskaya O, Kramer GM, Jones CD, Xie K, Martemyanov KA.
    Science Signaling (2015)

Not by weaving complex theories, not by building speculative philosophies, I desire a deep understanding of simple and beautiful truths.

増保 生郎 
Ikuo Masuho, PhD
E-mail: Ikuo.Masuho@outlook.jp

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