Publication list in Google Scholar Citations and ResearchGate
Rules and mechanisms governing G protein coupling selectivity of GPCRs.
Masuho I*, Kise R, Gainza P, Moo EV, Li X, Tany R, Wakasugi-Masuho H, Correia BE, and Martemyanov KA*.
Cell Reports (2023) [PubMed]
*Co-corresponding authors
Effects of Small Molecule Ligands on ACKR3 Receptors.
Hopkins BE, Masuho I, Ren D, Iyamu ID, Lv W, Malik N, Martemyanov KA, Schiltz GE, Miller RJ.
Molecular Pharmacology (2022) [PubMed]
Ligand-directed bias of G protein signaling at the dopamine D2 receptor.
Moo EV, Harpsøe K, Hauser AS, Masuho I, Bräuner-Osborne H, Gloriam DE, Martemyanov KA.
Cell Chemical Biology (2022) [PubMed]
Extended phenotyping and functional validation facilitate diagnosis of a complex patient harboring genetic variants in MCCC1 and GNB5 causing overlapping phenotypes.
Shao Z, Masuho I, Tumber A, Maynes JT, Tavares E, Ali A, Hewson S, Schulze A, Kannu P, Martemyanov KA, Vincent A.
Genes (2021) [PubMed]
Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling.
Masuho I*, Skamangas NK, Muntean BS, Martemyanov KA*.
Cell Systems (2021) [PubMed]
*Co-corresponding authors
Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders.
Muntean BS, Masuho I, Dao M, Sutton LP, Zucca S, Iwamoto H, Patil DN, Wang D, Birnbaumer L, Blakely RD, Grill B, Martemyanov KA.
Cell Reports (2021) [PubMed]
A global map of G protein signaling regulation by RGS proteins.
Masuho I, Balaji S, Muntean BS, Skamangas NK, Chavali S, Tesmer JJG, Babu MM, Martemyanov KA.
Cell (2020) [PubMed]
This paper was featured in Scripps Research Newsletter.
Haploinsufficiency as a disease mechanism in GNB1-associated neurodevelopmental disorder.
Schultz-Rogers L, Masuho I, Vairo FPE, Schmidtz CT, Schwab TL, Clark KJ, Gunderson L, Pichurin PN, Wierenga K, Martemyanov KA, Klee EW.
Molecular Genetics & Genomic Medicine (2020) [PubMed]
GPR139 signals via Gq/11 to oppose µ-opioid receptor actions.
Stoveken HM, Zucca S, Masuho I, Grill B, Martemyanov KA.
Journal of Biological Chemistry (2020) [PubMed]
GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells.
Anderson A, Masuho I, Marron Fernandez de Velasco E, Nakano A, Birnbaumer L, Martemyanov KA, Wickman K.
PNAS (2020) [PubMed]
Live cell optical assay for precise characterization of receptors coupling to Gα12.
Masuho I, Skamanagas NK, Martemyanov KA.
Basic & Clinical Pharmacology & Toxicology (2020) [PubMed]
Genetic behavioral screen identifies an orphan anti-opioid system.
Wang D, Stoveken HM, Zucca S, Dao M, Orlandi C, Song C, Masuho I, Johnston C, Opperman KJ, Giles AC, Gill MS, Lundquist EA, Grill B, Martemyanov KA.
Science (2019) [PubMed]
Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling.
Masuho I, Chavali S, Muntean BS,Skamangas NK, Simonyan K, Patil DN, Kramer GM, Ozelius L, and Babu MM, Martemyanov KA
Cell Reports (2018) [PubMed]
This paper was featured as GenScript Citation Star.
PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2
Desbois M, Crawley O, Evans PR, Baker ST, Masuho I, Yasuda R, Grill B
J. Bio.Chem. (2018) [PubMed]
Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.
Gulati S, Jin H, Orban T, Masuho I, Orban T, Cai Y, Pardon E, Martemyanov KA, Kiser PD, Stewart PL, Ford CP, Steyaert J, Palczewsk K
Nature Communications (2018) [PubMed]
RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells.
Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Yardena Samuels Y
Scientific Reports (2018) [PubMed]
Pharmacogenomics of GPCR drug targets.
Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM
Cell (2018) [PubMed] [YouTube]
This paper was highlighted in Science Signaling under "EDITORS' CHOICE" and was featured as GenScript Citation Star.
Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila.
Himmelreich S*, Masuho I*, Berry JA, MacMullen C, Skamangas NK, Martemyanov KA, Davis RL
Cell Reports (2017) [PubMed]
* These authors contributed equally to this work
LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1 -Rac1 pathway.
Carmon KS, Gong X, Yi J, Wu L, Thomas A, Moore CM, Masuho I, Timson DJ, Martemyanov KA, Liu QJ
J. Bio.Chem. (2017) [PubMed]
Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans.
Lohmann K*, Masuho I*, Patil DN, Baumann H, Hebert E, Steinrücke S, Trujillano D, Skamangas NK, Dobricic V, Hüning I, Gillessen-Kaesbach G, Westenberger A, Savic-Pavicevic D, Münchau A, Oprea G, Klein C, Rolfs A, Martemyanov KA
Human Molecular Genetics (2017) [PubMed]
*These authors contributed equally to this work
This paper was selected for journal cover page.
GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition.
Shamseldin HE*, Masuho I*, Anazi A, Yamani S, Patil DN, Martemyanov KA, Alkuraya FS
Genome Biology (2016) [PubMed]
*These authors contributed equally to this work
Synergistically acting agonists and antagonists of G protein–coupled receptors prevent photoreceptor cell degeneration.
Chen Y, PalczewskaG, Masuho I, Gao S, Jin H, Dong Z, Gieser L, Brooks MJ, Kiser PD, Kern TS, Martemyanov KA, Swaroop A, Palczewski K
Science Signaling (2016) [PubMed]
Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia.
Masuho I*, Fang M*, Geng C, Zhang J, Jiang H, Yarrow A, Myers A, Burn SC, Crotwell PL, Padilla-Lopez S, Dursun A*, Martemyanov KA*, Kruer MC*
Neurology Genetics (2016) [PubMed}
*These authors contributed equally to this work
Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function.
dos Santos CO, Masuho I, Pereira Júnior F, Barbosa ER, Cesar Azevedo Silva SM, Vanderci Borges V, Ferraz HB, Guimarães MS, Martemyanov KA, de Carvalho Aguiar P
Journal of Neurology (2016) [PubMed]
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
Masuho I, Ostrovskaya O, Kramer GM, Jones CD, Xie K, Martemyanov KA
Science Signaling (2015) [PubMed] [日本語要旨]
This paper was highlighted in Science Signaling under "Focus" section. [PubMed] and [PubMed]
This paper was featured in Promega Connections.
Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling
Xie K, Masuho I, Shih CC, Cao Y, Sasaki K, Lai CW, Han PL, Ueda H, Dessauer CW, Ehrlich ME, Xu B, Willardson BM, Martemyanov KA
eLife (2015) [PubMed]
Monitoring G protein activation in cells with BRET.
Masuho I, Martemyanov KA, Lambert NA
Methods Mol Bio. (2015) [PubMed]
Orphan receptor GPR158 is an allosteric modulator of RGS7 catalytic activity with an essential role in dictating its expression and localization in the brain.
Orlandi C, Xie K, Masuho I, Fajardo-Serrano A, Lujan R, Martemyanov KA
J. Biol. Chem. (2015) [PubMed]
G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization.
Octeau JC, Schrader JM, Masuho I, Sharma M, Aiudi C, Chen CK, Kovoor A, Celver J
PLoS One (2014) [PubMed]
RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.
Ostrovskaya O, Xie K, Masuho I, Fajardo-Serrano A, Lujan R, Wickman K, Martemyanov KA
eLife (2014) [PubMed]
Mutations in GNAL: a novel cause of craniocervical dystonia.
Kumar KR, Lohmann K, Masuho I, Miyamoto R, Ferbert A, Lohnau T, Kasten M, Hagenah J, Brüggemann N, Graf J, Münchau A, Kostic VS, Sue CM, Domingo AR, Rosales RL, Lee LV, Freimann K, Westenberger A, Mukai Y, Kawarai T, Kaji R, Klein C, Martemyanov KA, Schmidt A
JAMA Neurology (2014) [PubMed]
Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability.
Posokhova E, Ng D, Opel A, Masuho I, Tinker A, Biesecker LG, Wickman K, Martemyanov KA
PLoS One (2013) [PubMed]
Macromolecular composition dictates receptor and G protein selectivity of RGS7 and RGS9-2 protein complexes in living cells.
Masuho I, Xie K, Martemyanov KA
J. Biol. Chem. (2013) [PubMed]
Mutations in GNAL cause primary torsion dystonia.
Fuchs T, Saunders-Pullman R, Masuho I, Luciano MS, Raymond D, Factor S, Lang AE, Liang TW, Trosch RM, White S, Ainehsazan E, Hervé D, Sharma N, Ehrlich ME, Martemyanov KA, Bressman SB, Ozelius LJ
Nat. Genetics (2013) [PubMed]
Featured in "Faculty of 1000".
The complex of G protein regulator RGS9-2 and Gβ5 controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.
Xie K, Masuho I, Brand C, Dessauer CW, Martemyanov KA
Science Signaling (2012) [PubMed]
GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes.
Orlandi C, Posokhova E, Masuho I, Ray TA, Hasan N, Gregg RG, Martemyanov KA
J. Cell Biol. (2012) [PubMed]
Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.
Gopalakrishna KN, Doddapuneni K, Boyd KK, Masuho I, Martemyanov KM, Artemyev NO
J. Biol. Chem.. (2011) [PubMed]
Type 5 G protein beta subunit (Gβ5) controls the interaction of regulators of G protein signaling 9 (RGS9) with membrane anchors.
Masuho I, Wakasugi-Masuho H, Posokhova EN, Patton JR, Martemyanov KA
J. Biol. Chem. (2011) [PubMed]
Establishment of clonal cell lines of taste buds from a p53 (-/-) mouse tongue.
Sako H, Hori M, Masuho I, Saitoh O, Okada A, Tomooka Y
In Vitro Cell. Dev. Biol. Anim. (2011) [PubMed]
Membrane Anchoring Subunits Specify Selective Regulation of RGS9・Gβ5 GAP Complex in Photoreceptor Neurons.
Cao Y, Kolesnikov AV, Masuho I, Kefalov VJ, Martemyanov KA
J. Neurosci. (2010) [PubMed]
Featured in "Faculty of 1000".
Membrane anchor R9AP potentiates GAP activity of RGS11/Gβ5 complex and accelerates inactivation of the mGluR6-Go signaling.
Masuho I, Celver J, Kovoor A, Martemyanov KA
J. Biol. Chem. (2010) [PubMed]
Retina-specific GTPase accelerator RGS11/Gβ5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons.
Cao Y, Masuho I, Okawa H, Xie K, Asami J, Kammermeier PJ, Maddox DM, Furukawa T, Inoue T, Sampath AP, Martemyanov KA
J. Neurosci. (2009) [PubMed]
Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Gαo implicate significant roles of Gαo-GRIN1 signaling in nervous system.
Masuho I*, Mototani Y*, Sahara Y, Asami J, Nakamura S, Kozasa T, Inoue T
Developmental Dynamics (2008) [PubMed]
*These authors contributed equally to this work
Characterization of bitter taste responses of intestinal STC-1 cells.
Masuho I, Tateyama M, Saitoh O
Chem. Senses (2005) [PubMed]
The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Gα expression.
Masuho I, Itoh M, Itoh H, Saitoh O
J. Neurochem. (2004) [PubMed]
Distribution of regulator of G protein signaling 8 (RGS8) protein in the cerebellum.
Saitoh O, Masuho I, Itoh M, Abe H, Komori K, Odagiri M
The Cerebellum (2003) [PubMed]
Regulator of G protein signaling 8 (RGS8) requires its N-terminus for subcellular localization and acute desensitization of G protein-gated K+ channels.
Saitoh O, Masuho I, Terakawa I, Nomoto S, Asano T, Kubo Y
J. Biol. Chem. (2001) [PubMed]
Molecular cloning and characterization of Xenopus RGS5.
Saitoh O, Odagiri M, Masuho I, Nomoto S, Kinoshita N
Biochem. Biophys. Res. Commun. (2000) [PubMed]